Introduction:
A study from the Department of Orthopaedic Surgery, University of Michigan Medical School, USA; and Department of Molecular & Integrative Physiology, University of Michigan Medical School, USA shows that “Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice.” This study was published in the 15 March 2015 issue of the Journal “Aging cell” (the no.1 journal in aging research) by Prof. Faulkner JA, Mendias CL, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Amino acid based Lifespan extension therapy: L-Leucine, the branched chain essential amino acid, decreases the expression of Myostatin, inhibits aging-related decline in muscle function and enhances the longevity of mammals via up regulation of its target gene.
What is known?
Prof. Faulkner JA and his team had shown recently that deficiency of myostatin protects against aging-related loss in muscle function and extends the maximum lifespan of mice.
From Significance of the study to Therapeutic opportunity:
Myostatin is known to function as a key modulator of muscle mass and function. This study suggests, for the first time, that L-Leucine, by increasing the expression of its target gene, it may protect against aging-related loss of muscle function. And, thereby, extend the maximum lifespan of mice.
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Together, this study suggests that pharmacological formulations encompassing “L-Leucine or its analogs, either alone or in combination with other drugs,” may be used to enhance enhance longevity.
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Amount: $100#
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Undisclosed mechanistic information: How does Leucine inhibits the expression of Myostatin?
# Research cooperation
References:
Web: http://genomediscovery.org or newbioideas.com
To cite: Boominathan, L., Amino acid based Lifespan extension therapy: L-Leucine, the branched chain essential amino acid, decreases the expression of Myostatin, inhibits aging-related decline in muscle function and enhances the longevity of mammals via up regulation of its target gene, 25/May/2016, 11.15 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
* Research cooperation