From Significance of the study to Public health relevance:
Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.
Research findings to Therapeutic opportunity:
A number of studies suggests that Narrow-band ultraviolet B inhibits tumor cell proliferation. However, the mechanism of action is far from clear.
This study suggests that Narrow-band ultraviolet B, by regulating the expression of its target genes, it may increase the expression of metastasis suppressors TIMP3 and CCM3/KRIT1 (fig. 1).
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Thereby, it may: (a) inhibit cell cycle progression; and (d) suppress migration, invasion and metastasis of cancer cells.
Thus, Narrow-band ultraviolet B-based therapy may be advised for metastatic cancer patients to (i) increase the expression of metastasis suppressor genes in tumors; (ii) inhibit the progression of metastatic tumors; and (ii) enhance the efficacy of Cancer therapy. Together, oncologists may consider adopting Narrow-band ultraviolet B-based therapy in the treatment of Cancer.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $10
Undisclosed mechanistic information: How Narrow-band ultraviolet B increases the expression of metastasis suppressors TPM1 (Tropomyosin 1) and Tp63
Fig1. Mechanistic insights into how Narrow-band ultraviolet B functions as an anti-metastasis agent. Narrow-band ultraviolet B increases the expression of metastasis suppressors CCM3/KRIT1 and TIMP3 via down regulation of its target genes.
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References:
Citation: Boominathan, L., Narrow-band ultraviolet B therapy for Metastatic cancers: Narrow-band ultraviolet B increases the expression of metastasis suppressors TIMP3 and CCM3/KRIT1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 6/June/2017, 12.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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