What we say:
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Combinatorial therapy for Deafness: A therapeutic mix encompassing D-Allulose/D-Psicose, Cholecalciferol, Ajoene and DIM (ACAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes
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From Significance of the study to Public health relevance:
Given that: (1) more than one seventh of the global population suffers from hearing impairment; (2) majority of hearing impairment occurs in low and middle income countries, for instance, 3 in 1000 from developed countries, while 6 in 1000 from developing countries suffer from hearing impairment; (3) damage to the auditory hair cells (HCs) is the principal reason for hearing loss; (4) only in 50% cases hearing impairment can be cured; and (5) the global annual economic cost spent for unaddressed hearing loss is estimated to be in the range of $750–790 billions, there is an urgent need to find: (i) a way to promote regeneration, growth and proliferation of auditory hair cells in mammalian cochlea; (ii) a cheaper alternative to the existing expensive drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, hearing impairment.
From research findings to Therapeutic opportunity:
This study provides, for the first time, mechanistic insights into how a pharmaceutical mixture encompassing D-Allulose/D-Psicose (a non-caloric sugar/sweetener), Cholecalciferol, Ajoene and DIM (ACAD) may aid in the treatment of hearing impairment.
ACAD, by increasing the expression of its target genes, it may increase the expression of ATG5 (Autophagy-related protein 5). Thereby, it may: (1) prevent degeneration of adult hair cells; (2) prevent aggregation of polyubiquitinated proteins and p62/SQSTM1 in inclusion bodies; (3) promote maintenance of hair cells morphology and hearing acuity; and (4) prevent hearing loss. Thus, pharmacological mixture encompassing ” D-Allulose/D-Psicose, Cholecalciferol, Ajoene and DIM (ACAD) or their analogues, either alone or in combination with other drugs, may be used to treat deafness (Fig.1).
Figure 1 Mechanistic insights into how a therapeutic mix encompassing D-Allulose/D-Psicose, Cholecalciferol, Ajoene and DIM (ACAD) aids in improving hearing impairment. ACAD prevents aggregation of proteins, promotes regeneration of adult hair cells and inhibits hearing impairment via up-regulation of its target gene ATG5
Figure 2. The chemical structure of D-Allulose/D-Psicose. D-Allulose protects against hearing loss through induction of ATG5.
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Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does a therapeutic mix encompassing D-Allulose/D-Psicose, Cholecalciferol, Ajoene and DIM (SCAD) increase the expression of ATG5?
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References:
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Citation: Boominathan, L., A sweet tool in the control of Deafness: A therapeutic mix encompassing D-Allulose/D-Psicose, Cholecalciferol, Ajoene and DIM (ACAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes, 16/April/2018, 6.59 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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