Introduction: What they say:
The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function.
What we say:
In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports, for the first time, that: Anti-telomerase cancer therapy: CGI-58/ABHD5 (Comparative gene identification-58/α/β-hydrolase domain-containing 5) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene
Significance of the study:
Given that: (1) over 90% human tumors overexpress immortality gene telomerase; and (2) cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a way to inhibit telomerase activity in human tumors; (ii) a way to increase the efficacy of anticancer therapy; (iii) a cheaper alternative to the existing expensive drugs; (iv) a side-effect-free natural product-based drug; (v) a way to effectively treat cancers that are resistant to anticancer drugs; (vi) a way to prevent tumor recurrence; and (vii) a way to effectively treat and eradicate metastatic progression of cancer.
From Research Findings to Therapeutic opportunity:
This study suggests that CGI-58/ABHD5, by regulating the expression of its downstream target genes (Fig. 1), it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and Telomerase (Fig 1). Remarkably, over 90% of the human tumors overexpress the cellular immortality gene telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.
Taken together, pharmacological formulations encompassing “CGI-58/ABHD5 activators or CGI-58/ABHD5 activators in combination with other anticancer drugs” may be considered to treat human cancers that specifically overexpress the cellular immortality gene telomerase.
Details of the Research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How CGI-58/ABHD5 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase?
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Citation: Boominathan, L., Anti-telomerase cancer therapy: CGI-58/ABHD5 (Comparative gene identification-58/α/β-hydrolase domain-containing 5) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 17/February/2017, 10.48 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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