Cancer

December 9, 2018

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing lncRNA Hand2-AS1 and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TPM1, CCM3/KRIT1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 9/December/2018, `10.34 pm

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing lncRNA Hand2-AS1 and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TPM1, CCM3/KRIT1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 9/December/2018, `10.34 pm https://genomediscovery.org/wp-content/uploads/2018/12/LncRNA-Hand2AS1-and-the-probiotic-Lactobacillus-suppresses-metastatic-tumor-progressison-through-induction-of-TPM1-and-CCM3.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2018/12/LncRNA-Hand2AS1-and-the-probiotic-Lactobacillus-suppresses-metastatic-tumor-progressison-through-induction-of-TPM1-and-CCM3.jpg December 9, 2018 December 9, 2018

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in…

December 9, 2018

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Pimozide, an antipsychotic drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TIMP3, BTG2, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 9/December/2018, `10.25 pm

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Pimozide, an antipsychotic drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TIMP3, BTG2, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 9/December/2018, `10.25 pm https://genomediscovery.org/wp-content/uploads/2018/12/Neuroleptic-drug-Pimozide-functions-as-an-antitumor-agent-by-increasing-the-expression-of-tumor-suppressors-including-TIMP3-BTG2.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2018/12/Neuroleptic-drug-Pimozide-functions-as-an-antitumor-agent-by-increasing-the-expression-of-tumor-suppressors-including-TIMP3-BTG2.jpg December 9, 2018 December 9, 2018

December 8, 2018

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Pimozide, an antipsychotic drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as KIBRA, p57Kip2, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 8/December/2018, 7.26 pm

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Pimozide, an antipsychotic drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as KIBRA, p57Kip2, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 8/December/2018, 7.26 pm https://genomediscovery.org/wp-content/uploads/2018/12/Neuroleptic-drug-Pimozide-functions-as-an-anti-tumor-agent-by-increasing-the-expression-of-tumor-suppressors-including-TPM1-CCM3.KRIT1_.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2018/12/Neuroleptic-drug-Pimozide-functions-as-an-anti-tumor-agent-by-increasing-the-expression-of-tumor-suppressors-including-TPM1-CCM3.KRIT1_.jpg December 8, 2018 December 8, 2018

December 6, 2018

A sweet way to treat Metastatic cancers: Xylobiose, a disaccharide of xylose, increases the expression of tumor/metastatic suppressors LATS1 and SMARCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up-regulation of its target gene, 6/December/2018, 10.38 pm

A sweet way to treat Metastatic cancers: Xylobiose, a disaccharide of xylose, increases the expression of tumor/metastatic suppressors LATS1 and SMARCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up-regulation of its target gene, 6/December/2018, 10.38 pm https://genomediscovery.org/wp-content/uploads/2018/12/Prebiotic-Xylobiose-functions-as-an-anti-tumor.metastasis-by-increasing-the-expression-of-tumor.metastasis-suppressors.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2018/12/Prebiotic-Xylobiose-functions-as-an-anti-tumor.metastasis-by-increasing-the-expression-of-tumor.metastasis-suppressors.jpg December 6, 2018 December 6, 2018

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

December 6, 2018

Probiotic-based chemotherapy for “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: A pharmaceutical composition encompassing Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, and Lactobacillus Rhamnosus increases the expression of tumor suppressors genes, such as PTPN14, p12DOC1, TA-p73/p63, p53 and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene , 6/December/2018, 3.24 pm

Probiotic-based chemotherapy for “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: A pharmaceutical composition encompassing Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, and Lactobacillus Rhamnosus increases the expression of tumor suppressors genes, such as PTPN14, p12DOC1, TA-p73/p63, p53 and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene , 6/December/2018, 3.24 pm https://genomediscovery.org/wp-content/uploads/2018/12/Valsartan-and-probiotic-Lactobacillus-rhamnosus-functions-as-an-anti-tumor.metastasis.jpg1_.jpg2_.jpg3_.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2018/12/Valsartan-and-probiotic-Lactobacillus-rhamnosus-functions-as-an-anti-tumor.metastasis.jpg1_.jpg2_.jpg3_.jpg December 6, 2018 December 6, 2018

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

December 5, 2018

Probiotic-based therapy for Metastatic cancers: Probiotic Lactobacillus rhamnosus decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion, and metastasis of cancer cells, via up regulation of its target gene, 5/December/2018, 10.44 pm

Probiotic-based therapy for Metastatic cancers: Probiotic Lactobacillus rhamnosus decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion, and metastasis of cancer cells, via up regulation of its target gene, 5/December/2018, 10.44 pm https://genomediscovery.org/wp-content/uploads/2018/12/Probiotic-Lactobacillus-rhamnosus-inhibits-migration-invasion-and-metastasis-of-cancer-cells-through-down-regulation-of-PPM1F.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2018/12/Probiotic-Lactobacillus-rhamnosus-inhibits-migration-invasion-and-metastasis-of-cancer-cells-through-down-regulation-of-PPM1F.jpg December 5, 2018 December 5, 2018

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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