Cancer

September 28, 2018

Activating tumor suppressor gene network for cancer therapeutics: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as LATS1, SMARCA4, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/September/2018, 7.49 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 28, 2018

Turning on the cancer-protecting tumor suppressor network in mutant p53-expressing human tumors: Andrographolide, isolated from Andrographis paniculata, increases the expression of tumor suppressors genes, such as BTG2, CADM1, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/September/2018, 7.14 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 28, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Mibolerone (Trade name: Cheque drops and Matenon), an anabolic-androgenic steroid, increases the expression of tumor suppressors genes, such as FOXO1, APAF1, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/September/2018, 6.29 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 21, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Mibolerone (Trade name: Cheque drops and Matenon), an anabolic-androgenic steroid, increases the expression of tumor suppressors genes, such as IGFBP3, PIAS3, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 21/September/2018, 10.02 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]