Cardiac hypertrophy and fibrosis

February 5, 2019

Ribonucleic acid-based therapy for cardiac hypertrophy and fibrosis: lncRNA PCGEM  decreases MiR-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 5/January/2019, 10.06 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
December 13, 2018

AP-1-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: AP-1 (Activator protein-1) increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 13/December/2018, 11.16 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
November 28, 2018

Molecular therapy for enhanced learning, memory, and cognitive ability: AP-1 (Activator protein-1), comprising c-Jun and c-fos and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 28/November/2018, 1.25 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
November 28, 2018

Hot-water immersion therapy may safeguard your heart against cardiac dysfunction: Hot-water immersion therapy ( at 39°C for 1 hour) for cardiomyocyte proliferation and heart regeneration: Hot-water immersion therapy decreases tumor suppressor Mir-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 28/September/2018, 12.13 am

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]