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Cardiac hypertrophy and fibrosis

November 15, 2018

Molecular therapy for cardiac dysfunction: Empagliflozin (trade name: Jardiance), used in the treatment of TIIDM, decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function, via upregulation of its target gene, 15/November/2018, 11.22 pm

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
October 28, 2018

Melodious music functions as a protector of your myocardium: Music increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up-regulation of its target gene, 28/December/2017, 2.07 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
October 18, 2018

The tiny probiotic may safeguard your heart against cardiac dysfunction: Probiotic Lactobacillus pentosus var.plantarum C29-based therapy for cardiomyocyte proliferation and heart regeneration: Probiotic Lactobacillus pentosus var.plantarum C29 decreases tumor suppressor Mir-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 18/Ocotober/2018, 11.01 pm

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
September 28, 2018

Consuming a Probiotic once a day may insulate your heart against cardiac dysfunction: Probiotic Bifidobacterium Breve-based adjunct therapy for cardiac hypertrophy and fibrosis: Probiotic Bifidobacterium Breve decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 28/September/2018, 3.09 pm

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]