Ideas

Repurposing the anti-hypertensive agent into an anti-malarial agent: Nifidipine, a calcium channel blocker, increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 28/February/2020, 9.39 am
Repurposing the anti-hypertensive agent into an anti-malarial agent: Nifidipine, a calcium channel blocker, increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 28/February/2020, 9.39 am 960 720 Dr Boomi's Genom-2-Discovery Center

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma/Therapeutic/Clinical ideas posted today (28/February/2020) will be…

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Repurposing the anti-asthmatic agent Tranilast into an anti-HIV agent: Tranilast (trade name: Rizaben and others) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 26/February/2020, 11.07 pm
Repurposing the anti-asthmatic agent Tranilast into an anti-HIV agent: Tranilast (trade name: Rizaben and others) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 26/February/2020, 11.07 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-asthmatic agent Tranilast into an anti-HIV agent: Tranilast (trade name: Rizaben and others) increases Heme…

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Molecular therapy for body weight control, energy homeostasis and TIIDM: TICAM1/TRIF[Toll-like receptor adaptor molecule1/TIR-domain-containing adapter-inducing interferon-beta] decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 24/February/2020, 11.12 pm
Molecular therapy for body weight control, energy homeostasis and TIIDM: TICAM1/TRIF[Toll-like receptor adaptor molecule1/TIR-domain-containing adapter-inducing interferon-beta] decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 24/February/2020, 11.12 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule…

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Repurposing the anti-hypertensive agent Carvedilol into an anti-HIV agent: Carvedilol (trade name: Coreg and others)) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 22/February/2020, 11.19 pm
Repurposing the anti-hypertensive agent Carvedilol into an anti-HIV agent: Carvedilol (trade name: Coreg and others)) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 22/February/2020, 11.19 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-hypertensive agent Carvedilol into an anti-HIV agent: Carvedilol (trade name: Coreg and others)) increases Heme…

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Mechanistic insights into how Blue zone longevity diet protects against cardiac dysfunction: Having honey on a daily basis will protect you against cardiac dysfunction and extend lifespan:Chrysin, found in propolis and honey, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/February/2020, 8.10 pm
Mechanistic insights into how Blue zone longevity diet protects against cardiac dysfunction: Having honey on a daily basis will protect you against cardiac dysfunction and extend lifespan:Chrysin, found in propolis and honey, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/February/2020, 8.10 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD. From research findings to Therapeutic opportunity:  Blue zone longevity diet, consumed by long-lived people from blue zone, such as Okinawa…

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Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate  (trade name: Fenoglide, Lipofen, Tricor and others)), an antilipidemic drug, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 20/February/2020, 9.39 am
Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate  (trade name: Fenoglide, Lipofen, Tricor and others)), an antilipidemic drug, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 20/February/2020, 9.39 am 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate  (trade name: Fenoglide, Lipofen, Tricor and others)), an…

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