Ideas

July 29, 2019

Solving a seventy plus year puzzle as to how labor pain relief medication Pethidine functions as a pain reliever: Mechanistic insights into how Pethidine  functions as an analgesic agent: Pethidine (trade name: Meperidine/Demerol), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 29/July/2019, 2.48 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 24, 2019

Solving a sixty plus year puzzle as to how Bupivacaine functions as a pain reliever: Mechanistic insights into how Bupivacaine functions as a local anesthetic agent: Bupivacaine  (trade name: Marcaine, Sensorcaine, Vivacaine, others ), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/July/2019, 6.34 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 23, 2019

Probiotic-based therapy for aging-associated diseases and Lifespan extension: A therapeutic mix encompassing Probiotic Bifidobacterium LKM512 and Arginine inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 23/July/2019, 8.03 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
July 21, 2019

Solving a sixty-year old puzzle as to how Amitriptyline functions as a pain reliever: Mechanistic insights into how Amitriptyline functions as a pain medication: Amitriptyline (trade name: Elatrol, Elatrolet, Elavil, Endep, Fiorda, Laroxyl, Latilin, Levate and others), used in the treatment for major depressive order, and anxiety disorders, prevention of migraines, fibromyalgia, postherpetic neuralgia, and insomnia,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/July/2019, 11.29 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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