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Ideas

June 1, 2018

Combinatorial therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing L-Malate, Lithium and Imidazopyridine derivative (X22) (MLX22) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 1/June/2018, 10.51 pm

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
June 1, 2018

Locking blood sugar disease with an interleukin therapy: Interleukin(IL-15)-based therapy for TIIDM: IL-15 increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 1/May/2018, 10.33 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
June 1, 2018

Unknown action of a known drug in learning/memory/cognitive-enhancement:Bromocriptine (trade name:Parlodel), used in the treatment of  pituitary tumors, Parkinson’s disease (PD), hyperprolactinaemia, infertility and others,  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down regulation of its target genes, 1/June/2018, 8.54 am

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
May 30, 2018

Interleukin-based therapy for glucose homeostasis and TIIDM: Interleukin-4 (IL-4) increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 30/May/2018, 6.11 am

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
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