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Ideas

May 30, 2018

A sweet way to strengthen your heart-too good to be true (!): Oligofructose-based therapy for cardiomyocyte proliferation and heart regeneration: Agavins (Oligofructose), isolated from Agavi, decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 30/May/2018, 5.41 am

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
May 27, 2018

Sleeping your way to live free of myocardial diseases: Melatonin-based therapy for Cardiac repair and myocardial infarction: Melatonin ( N-acetyl-5-methoxy tryptamine), a hormone known to regulate sleep and wakefulness, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 27/May/2018, 11.45 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
May 27, 2018

A glycolipid comes to rescue of blood sugar disease: α-Galactosylceramide-based regenerative therapy for reversing diabetes:  α-Galactosylceramide (α-GalCer), a synthetic glycolipid derived from Agelas mauritanius, increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 27/May/2018, 11.34 am

Introduction: What they say A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, […]
May 27, 2018

Sleeping your way to say no to cardiac diseases: Melatonin-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Melatonin, a hormone known to play a role in sleep and wakefulness, decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up regulation of its target gene, 27/May/2018, 7.21 am

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]
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