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Ideas

April 10, 2018

Natural product-based therapy for CyclinD3-CDK6 overexpressing cancers: Nimbolide, isolated from Azadirachta indica, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 10/April/2018, 6.41 pm

Introduction: What they say A study from Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; and Department of Genetics, Harvard Medical School, Boston, Massachusetts, […]
April 10, 2018

Natural product-based therapy for blood-stage Plasmodium infection: Moringin, isolated from moringa olifera, decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 10/April/2018, 6.29 pm

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]
April 10, 2018

Combinatorial therapy for gynecologic cancers: A therapeutic mix encompassing  Calcitriol, Mitoxantrone, Despiramine, 17DMAG, Salinomycin, Lovastatin, and Jasmonate inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 10/April/2018, 6.05 pm

Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on […]
April 9, 2018

An omega-3 way to treat pain:  PUFA-based activation of the PD-1 pathway for Pain therapy:  ω-PUFAs (Docosahexaenoic acid (DHA) + Eicosapentaenoic acid (EPA) increase the expression of PD-L1, attenuate acutes and chronic pain, suppress mechanical and thermal hypersensitivity and inhibit nociceptive neuron excitability, via up-regulation of its target gene, 9/April/2018, 6.31 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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