Ideas

June 20, 2019

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in chronic lymphocytic leukemia (CLL) and in advanced metastatic cancers: A pharmaceutical mixture encompassing Venetoclax and Ibrutinib (VAI) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as HNF4α, PP2A, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls CLL progression, via up-regulation of its target gene, 20/June/2019, 7.33 am

Introduction: What they say A study from the University of Texas M.D. Anderson Cancer Center, Houston, USA shows that “Ibrutinib and Venetoclax for First-Line Treatment of CLL.” This research […]
June 20, 2019

Mechanistic insights into how Liraglutide aids in remission of Diabetes: Liraglutide (brand name: Victoza, Saxenda and others), a  drug used in the treatment of type II diabetes, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia, via downregulation of  Sox4 and its target gene Amysin,  20/June/2019, 7.13 am

Introduction: What they say  Nobel laureate [ in Physiology/Medicine in 1975] Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in the September 14, […]
June 18, 2019

Ciliary neurotrophic factor (CNTF)-based curative therapy for autoimmune diabetes (TIDM):  Ciliary neurotrophic factor (CNTF)  increases the expression of PD-L1, decreases the expression of TXNIP, augments Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 18/June/2019, 10.56 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
June 17, 2019

Solving a century-old puzzle as to how Sesame oil functions as a pain reliever: Mechanistic insights into how Sesame oil-derived compounds function as pain medications: A pharmaceutical mixture encompassing Sesamin and Sesamol (SAS), derived from Sesame seed or oil,  increases the expression of PD-L1, decreases the expression of Cox-2, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/June/2019, 12.58 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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