Ideas

March 31, 2020

Published by admin_auro at March 31, 2020

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A vaccine against SARS-COV-2: Repurposing the tuberculosis BCG vaccine into a Prophylactic COVID-19 vaccine: BCG vaccine inhibits SARS-COV-2, Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, Interferon-stimulated gene 15, and others 1/April/2020, 1.29 am

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]

March 10, 2020

Published by admin_auro at March 10, 2020

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Repurposing the anti-asthmatic drug Montelukast into an anti-tuberculosis drug: Montelukast (trade name: Singulair) deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 10/March/2020, 8.01 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]

March 10, 2020

Published by admin_auro at March 10, 2020

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Anti-asthmatic drug comes to the rescue of blood-stage Plasmodium infection: Pranlukast, an anti-asthmatic drug, decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clears blood-stage malaria, via up regulation of its target gene, 10/March/2020, 7.38 am

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]

March 10, 2020

Published by admin_auro at March 10, 2020

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Mechanistic insights into how Vitamin D3/Cholecalciferol enhances immunity against bacterial infections: Cholecalciferol-based immune enhancement therapy: Low dose Cholecalciferol/Vitamin-D3 increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 10/March/2020, 6.18 am

Introduction: What they say: A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]