Ideas

Amino acid-based Regenerative therapy for muscle atrophy: L-Arginine, a non-essential amino acid, increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 25/February/2017, 11.46 pm
Amino acid-based Regenerative therapy for muscle atrophy: L-Arginine, a non-essential amino acid, increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 25/February/2017, 11.46 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, China shows that “miR-29b contributes to multiple types of…

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Activation of the PD-1 pathway for Pain therapy: A therapeutic mix encompassing tramadol and ketamine increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 25/February/2017, 10.43 pm
Activation of the PD-1 pathway for Pain therapy: A therapeutic mix encompassing tramadol and ketamine increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 25/February/2017, 10.43 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Natural product-based therapy for Non-alcoholic fatty liver disease (NAFLD):  Syringic acid promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 25/February/2018, 10.36 pm
Natural product-based therapy for Non-alcoholic fatty liver disease (NAFLD):  Syringic acid promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 25/February/2018, 10.36 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in…

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Cardiac rejuvenation therapy: A therapeutic mix encompassing Pyridoxamine and L-Arginine suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene, 25/February/2018, 10.26 pm
Cardiac rejuvenation therapy: A therapeutic mix encompassing Pyridoxamine and L-Arginine suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene, 25/February/2018, 10.26 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Cardiac rejuvenation therapy: A therapeutic mix encompassing Pyridoxamine and L-Arginine suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via…

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Activation of the PD-1 pathway for Pain therapy: Venlafaxine (brand name: effexor), an antidepressant which functions as a selective serotonin-norepinephrine reuptake inhibitor, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 25/February/2017, 10.16 pm
Activation of the PD-1 pathway for Pain therapy: Venlafaxine (brand name: effexor), an antidepressant which functions as a selective serotonin-norepinephrine reuptake inhibitor, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 25/February/2017, 10.16 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Molecular therapy for body weight control, energy homeostasis and TIIDM: Syringic acid decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 25/February/2017, 9.58 pm
Molecular therapy for body weight control, energy homeostasis and TIIDM: Syringic acid decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 25/February/2017, 9.58 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.”…

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