Ideas

August 18, 2018

Published by admin_auro at August 18, 2018

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Insulate your heart against cardiac dysfunction with H.Pylori CTB-UE vaccine: H.Pylori CTB-UE vaccine-based adjunct therapy for cardiac hypertrophy and fibrosis: H.Pylori CTB-UE vaccine decreases MiR-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 18/August/2018, 11.41 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]

August 18, 2018

Published by admin_auro at August 18, 2018

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as BTG2, PDCD4,p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 18/August/2018, 11.23 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

August 17, 2018

Published by admin_auro at August 17, 2018

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A Relaxin(g)-way to say no to cardiac diseases: Relaxin-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Relaxin, a reproductive hormone, decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up-regulation of its target gene, 18/August/2018, 1.11 am

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]

August 17, 2018

Published by admin_auro at August 17, 2018

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Cancer
Ideas

Unknown function of the known steroid hormone in targeting cancer stem cells in Myeloid leukaemia (ML): Progesterone (P4), a steroid hormone, inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 18/August/2017, 12.31 am

Introduction to what they say: A study from the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem […]