Natural product-based therapy for TIIDM and obesity-associated metabolic deficits: A therapeutic mix encompassing Aspalathin and Nothofagin, isolated from Rooibos, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 11/January/2018, 10.37 pm
Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite by bone-derived lipocalin 2.” This research paper was published, in the 8 March 2017 issue of the journal “Nature” [One of the best research journals in General Science with an I.F […]
Anti-infective Therapy: Fluvastatin, a lipid-lowering drug used in the treatment of hypercholesterolemia and cardiovascular disease, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 10/January/2017, 11.11 pm
Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the […]
Lifespan extension therapy: Candesartan, an angiotensin II receptor antagonist used mainly in the treatment of hypertension, may increase life span via up-regulation of its target gene BubR1, 10/January/2017, 7.02 pm
What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the […]
Molecular therapy for Metastatic cancers: Torasemide, an anti-hypertensive drug, increases the expression of tumor suppressors PDCD4 and PTEN, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 10/January/2017, 6.52 pm
From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes […]
Lifespan extension therapy: Atorvastatin (Trade name: Lipitor), a lipid-lowering agent, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 10/January/2017, 6.38 pm,
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that Atorvastatin, by increasing the expression […]
Vitamin-based Combinatorial therapy for reversing TIIDM: A pharmaceutical mixture encompassing Pyridoxamine and Sulforaphane (PMSFN) augments the expression of FGF19 and FGF1, attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIIDM via up regulation of its target gene, 10/January/2017, 6.24 pm
Introduction: What they say A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained remission of diabetic hyperglycemia in rodents. This research paper was published, in the 23 May 2016 issue of the journal “Nature Medicine” [One of the […]