Ideas

Molecular therapy for body weight control, energy homeostasis and TIIDM: α-lipoic acid, isolated from Broccoli and Tomato, among others, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/January/2017, 12.20 am
Molecular therapy for body weight control, energy homeostasis and TIIDM: α-lipoic acid, isolated from Broccoli and Tomato, among others, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/January/2017, 12.20 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator of adipose insulin resistance.”…

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Molecular therapy for Metastatic cancers: Torasemide, an anti-hypertensive drug, increases the expression of tumor/metastasis suppressors BTG2 and INK4a/p16, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 10/January/2017, 12.13 am
Molecular therapy for Metastatic cancers: Torasemide, an anti-hypertensive drug, increases the expression of tumor/metastasis suppressors BTG2 and INK4a/p16, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 10/January/2017, 12.13 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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Life-extension therapy: Tomatidine, isolated from unripe tomoto, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 9/January/2017, 11.59 pm
Life-extension therapy: Tomatidine, isolated from unripe tomoto, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 9/January/2017, 11.59 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Lifespan extension therapy:  Telmisartan [Brand name: Micardis], an anit-hypertensive medication, increases life span via up-regulation of its target gene BubR1, 9/January/2017, 11.47 pm
Lifespan extension therapy:  Telmisartan [Brand name: Micardis], an anit-hypertensive medication, increases life span via up-regulation of its target gene BubR1, 9/January/2017, 11.47 pm 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Vitamin-based Combinatorial therapy for reversing TIIDM: A pharmaceutical mixture encompassing Pyridoxamine and Vitamin K1 (PMVK1)augments the expression of FGF19 and FGF1,   attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIIDM via up regulation of its target gene, 9/January/2017, 11.39 pm
Vitamin-based Combinatorial therapy for reversing TIIDM: A pharmaceutical mixture encompassing Pyridoxamine and Vitamin K1 (PMVK1)augments the expression of FGF19 and FGF1,   attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIIDM via up regulation of its target gene, 9/January/2017, 11.39 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained…

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Molecular therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing α-lipoic acid, Epicatechin and Marine (LAEM)  inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 8/January/2018, 10.56 pm
Molecular therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing α-lipoic acid, Epicatechin and Marine (LAEM)  inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 8/January/2018, 10.56 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for Cardiovascular Research (DZHK) partner…

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