Ideas

Natural product-based therapy for body weight control, energy homeostasis and TIIDM: Carvedilol[Trade name: Coreg], Nonselective beta/alpha1 blocker used in the treatment of myocardial dysfunction and hypertension, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/December/2017, 9.59 am
Natural product-based therapy for body weight control, energy homeostasis and TIIDM: Carvedilol[Trade name: Coreg], Nonselective beta/alpha1 blocker used in the treatment of myocardial dysfunction and hypertension, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/December/2017, 9.59 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator of adipose insulin resistance.”…

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Activation of the PD-1 pathway for Pain therapy: Punicalagin, isolated from Pomegranate,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 10/December/2017, 7.13 am
Activation of the PD-1 pathway for Pain therapy: Punicalagin, isolated from Pomegranate,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 10/December/2017, 7.13 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Amino acid-based therapy for Non-alcoholic fatty liver disease (NAFLD): D-Serine promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD) via down regulation of its target gene, 10/December/2017, 6.07 am
Amino acid-based therapy for Non-alcoholic fatty liver disease (NAFLD): D-Serine promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD) via down regulation of its target gene, 10/December/2017, 6.07 am 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; (2) 75 to 100 million…

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Lifespan extension therapy:  Naringenin, isolated from from Grapefruits, increases life span via up-regulation of its target gene BubR1, 10/December/2017, 6.21 am
Lifespan extension therapy:  Naringenin, isolated from from Grapefruits, increases life span via up-regulation of its target gene BubR1, 10/December/2017, 6.21 am 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Amino acid-based therapy for body weight control, energy homeostasis and TIIDM: D-Serine increases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 10/December/2017, 6.01 am
Amino acid-based therapy for body weight control, energy homeostasis and TIIDM: D-Serine increases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 10/December/2017, 6.01 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.” This research paper…

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Natural product-derived therapy for improving cardiac contractility and attenuating pathogenesis associated with Myocardial infarction: β-Cryptoxanthin, Mangiferin and Glycyrrhetinic acid(CMG) decreases GRK2 (G Protein-Coupled Receptor Kinase 2) and GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, increases cardiac contractility, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, promotes heart healing and inhibits glucose intolerance, via up regulation of its target gene, 9/December/2017, 12.20 pm
Natural product-derived therapy for improving cardiac contractility and attenuating pathogenesis associated with Myocardial infarction: β-Cryptoxanthin, Mangiferin and Glycyrrhetinic acid(CMG) decreases GRK2 (G Protein-Coupled Receptor Kinase 2) and GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, increases cardiac contractility, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, promotes heart healing and inhibits glucose intolerance, via up regulation of its target gene, 9/December/2017, 12.20 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study, from Department of Medicine, Division of Cardiology, Dept of Cell Biology, and Department of Molecular Genetics, Duke University Medical Center, Durham, North Carolina,…

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