Ideas

Molecular therapy for Deafness: A therapeutic mix encompassing Clomipramine, Cholecalciferol, Ajoene and DIM (CCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 10/November/2017, 8.59 am
Molecular therapy for Deafness: A therapeutic mix encompassing Clomipramine, Cholecalciferol, Ajoene and DIM (CCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 10/November/2017, 8.59 am 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Deafness: A therapeutic mix encompassing Clomipramine, Cholecalciferol, Ajoene and DIM (CCAD)  increases the expression of ATG5 (Autophagy-related 5),…

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Activation of the PD-1 pathway for Pain therapy: Fluoxetine, an anti-depressant,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene,10/November/2017, 9.00 am
Activation of the PD-1 pathway for Pain therapy: Fluoxetine, an anti-depressant,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene,10/November/2017, 9.00 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Molecular therapy for attenuating pathogenesis of Myocardial infarction: Rivoglitazone, an anti-diabetic medication, decreases GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, and promotes heart healing via up regulation of its target gene, 10/November/2017, 9.01 am
Molecular therapy for attenuating pathogenesis of Myocardial infarction: Rivoglitazone, an anti-diabetic medication, decreases GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, and promotes heart healing via up regulation of its target gene, 10/November/2017, 9.01 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; and Center for Systems Biology, Massachusetts General Hospital…

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Molecular therapy for anxiety and depression:  Agmatine decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 10/November/2017, 9.03 am
Molecular therapy for anxiety and depression:  Agmatine decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 10/November/2017, 9.03 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department of Stem Cell and…

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Molecular therapy for heart regeneration and repair: A therapeutic mix encompassing Efonidipine and Verapamil, anti-hypertensive drugs, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 8/November/2017, 11.43 pm
Molecular therapy for heart regeneration and repair: A therapeutic mix encompassing Efonidipine and Verapamil, anti-hypertensive drugs, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 8/November/2017, 11.43 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708,…

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Natural product therapy for body weight control, energy homeostasis and TIIDM:  Linalool, found in coriander oil, sweet orange (Citrus sinensis), tomato,  oils of rose, neroli, lavender, laurel and sweet basil (Ocimum basilicum) among others, decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 8/November/2017, 11.00 pm
Natural product therapy for body weight control, energy homeostasis and TIIDM:  Linalool, found in coriander oil, sweet orange (Citrus sinensis), tomato,  oils of rose, neroli, lavender, laurel and sweet basil (Ocimum basilicum) among others, decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 8/November/2017, 11.00 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.”…

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