Ideas

May 17, 2019

Excess consumption of coffee during pregnancy increases the chances of spontaneous abortion, stillbirth & prenatal mortality: Caffeine increases DNA damage responses, suppresses telomerase expression, attenuates telomere shortening, inhibits cardiomyocyte survival, promotes cardiomyocytes apoptosis, and promotes myocardial dysfunction, via down-regulation of PNUTS, 17/May/2019, 11.22 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
May 17, 2019

Blood pressure drug Verapamil comes to the rescue of blood sugar disease: Verapamil (brand name: Calan, Isoptin and others), a calcium channel blocker that aids in the treatment of high blood pressure, angina pectoris, supraventricular tachyarrhythmias and others,   inhibitor used in the treatment of hyperglycemia,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 17/May/2019, 10.40 pm

 Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
May 17, 2019

Molecular therapy for attenuating pathogenesis-associated with Myocardial infarction: Canagliflozin  (Brand name: Invokana, Sulisent, Prominad, others), an anti-hyperglycemic medication used to treat type II diabetes, decreases GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, and promotes heart healing via up regulation of its target gene, 17/May/2019, 10.25 pm

Introduction: What they say: A recent study from Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; and Center for Systems […]
May 16, 2019

Natural product-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Carvacrol, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  TPM1, CADM1/2,  E-cadherin, p53, and TA-p73/p63, stalls cell cycle progression, inhibits immune-inhibitory receptors/molecules, suppresses cancer stem cell proliferation, inhibits migration, invasion and metastasis of cancer cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 16/May/2019, 10.52 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Natural product-based therapy targeting cancer stem […]
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