Ideas

Mechanistic insights into how Ginger-derived compounds function as antiviral agents: Ginger-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Zingerone, isolated from Ginger, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 4/June/2019, 11.01 am
Mechanistic insights into how Ginger-derived compounds function as antiviral agents: Ginger-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Zingerone, isolated from Ginger, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 4/June/2019, 11.01 am 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that…

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Curing diabetes with commonly available blood pressure drug Verapamil: Verapamil-based therapy for TIIDM and obesity-associated metabolic deficits: Verapamil  (trade name: Calan, Isoptin, and others), a calcium channel blocker used in the treatment of high blood pressure, angina and others, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, decreases TXNIP expression, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 04/June/2019, 7.48 am
Curing diabetes with commonly available blood pressure drug Verapamil: Verapamil-based therapy for TIIDM and obesity-associated metabolic deficits: Verapamil  (trade name: Calan, Isoptin, and others), a calcium channel blocker used in the treatment of high blood pressure, angina and others, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, decreases TXNIP expression, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 04/June/2019, 7.48 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite by…

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Sesame oil-based therapy for Deafness and presbycusis: A therapeutic mix encompassing Sesamin, sesamol, Cholecalciferol, Ajoene and DIM (SSCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 1/June/2019, 6.46 pm
Sesame oil-based therapy for Deafness and presbycusis: A therapeutic mix encompassing Sesamin, sesamol, Cholecalciferol, Ajoene and DIM (SSCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 1/June/2019, 6.46 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Sesame oil-based therapy for Deafness and presbycusis: A therapeutic mix encompassing Sesamin, sesamol, Cholecalciferol, Ajoene and DIM (SSCAD) increases the expression of…

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Zingerone as a broad-spectrum anti-infective agent:   Zingerone, one of the components of Ginger,  inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 1/June/2019,  6.04 pm
Zingerone as a broad-spectrum anti-infective agent:   Zingerone, one of the components of Ginger,  inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 1/June/2019,  6.04 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins…

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Chronic isolation stress promotes the development of type II diabetes mellitus and cardiovascular dysfunction: Chronic isolation stress decreases the expression of IGF1R, INSR, and IRS2, and inhibits insulin-sensitized state, via down-regulation of  its target gene Lin28, 1/June/2019, 5.55 pm
Chronic isolation stress promotes the development of type II diabetes mellitus and cardiovascular dysfunction: Chronic isolation stress decreases the expression of IGF1R, INSR, and IRS2, and inhibits insulin-sensitized state, via down-regulation of  its target gene Lin28, 1/June/2019, 5.55 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study…

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Drinking ginger tea will make you to shed off weight and and lower lipid levels: Zingerone, a natural compound found in cooked ginger, decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 31/May/2019, 3.12 pm
Drinking ginger tea will make you to shed off weight and and lower lipid levels: Zingerone, a natural compound found in cooked ginger, decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 31/May/2019, 3.12 pm 960 720 Dr Boomi's Genom-2-Discovery Center

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people…

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