Ideas

Natural sugar-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Xylobiose (a disaccharide of xylose, with a  a beta-1,4-bond), and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  SOCS6, APAF1, E-cadherin, p53, and TA-p73/p63, stalls cell cycle progression, inhibits immune-inhibitory receptors/molecules, suppresses cancer stem cell proliferation, inhibits migration, invasion and metastasis of cancer cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 20/May/2019, 12.47 am
Natural sugar-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Xylobiose (a disaccharide of xylose, with a  a beta-1,4-bond), and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  SOCS6, APAF1, E-cadherin, p53, and TA-p73/p63, stalls cell cycle progression, inhibits immune-inhibitory receptors/molecules, suppresses cancer stem cell proliferation, inhibits migration, invasion and metastasis of cancer cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 20/May/2019, 12.47 am 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Natural sugar-based therapy targeting cancer stem cells and immune-inhibitory receptors…

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Atrasentan-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Atrasentan, an endothelin receptor antagonist selective for subtype A (ETA) used to treat cancer, pulmonary hypertension, diabetic kidney diseases and others, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 20/May/2019, 12.39 am
Atrasentan-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Atrasentan, an endothelin receptor antagonist selective for subtype A (ETA) used to treat cancer, pulmonary hypertension, diabetic kidney diseases and others, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 20/May/2019, 12.39 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April…

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Essential oil-derived compound functions as an anti-HIV agent: Carvacrol increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 18/May/2017, 11.46 pm
Essential oil-derived compound functions as an anti-HIV agent: Carvacrol increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 18/May/2017, 11.46 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Essential oil-derived compound functions as an anti-HIV agent: Carvacrol increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1…

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Natural product-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Carvacrol increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 18/May/2019, 11.36 pm
Natural product-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Carvacrol increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 18/May/2019, 11.36 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that…

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Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA CCDC26  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 17/May/2019, 11.55 pm
Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA CCDC26  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 17/May/2019, 11.55 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA SNHG14  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 17/May/2019, 11.50 pm
Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA SNHG14  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 17/May/2019, 11.50 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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