Ideas

Treating cancers with longevity-promoting agents: Anticancer agent Bexarotene functions as a longevity-promoting agent: Bexarotene inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene, 8/May/2019, 7.13 am
Treating cancers with longevity-promoting agents: Anticancer agent Bexarotene functions as a longevity-promoting agent: Bexarotene inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene, 8/May/2019, 7.13 am 1280 720 Dr Boomi's Genom-2-Discovery Center

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Canagliflozin-based therapy for Cardiac repair and myocardial infarction: Canagliflozin (trade name: Invokana, Sulisent, Prominad, others), a sodium-glucose cotransporter 2 inhibitor used in the treatment of TIIDM, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up-regulation of its target gene, 8/May/2019,  6.59 am
Canagliflozin-based therapy for Cardiac repair and myocardial infarction: Canagliflozin (trade name: Invokana, Sulisent, Prominad, others), a sodium-glucose cotransporter 2 inhibitor used in the treatment of TIIDM, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up-regulation of its target gene, 8/May/2019,  6.59 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708,…

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Liraglutide-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Liraglutide (Brand name: Victoza, Saxenda, others), a GLP-1 receptor agonist used to treat TIIDM, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 7/May/2019, 6.36 am
Liraglutide-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Liraglutide (Brand name: Victoza, Saxenda, others), a GLP-1 receptor agonist used to treat TIIDM, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 7/May/2019, 6.36 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April…

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Mechanistic insights into how Canagliflozin protects against cardiomyopathy: Canagliflozin(Brand name: Invokana, Sulisent, Prominad), a sodium-glucose cotransporter-2 inhibitor used in the treatment of TIIDM, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy, via upregulation of its target gene, 7/May/2019, 6.17 am
Mechanistic insights into how Canagliflozin protects against cardiomyopathy: Canagliflozin(Brand name: Invokana, Sulisent, Prominad), a sodium-glucose cotransporter-2 inhibitor used in the treatment of TIIDM, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy, via upregulation of its target gene, 7/May/2019, 6.17 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This…

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Mechanistic insights into how analgesic agent Cannabidiol (CBD) attenuates pain: Cannabidiol (CBD), an analgesic drug derived from hemp and others, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 7/May/2019, 6.04 am
Mechanistic insights into how analgesic agent Cannabidiol (CBD) attenuates pain: Cannabidiol (CBD), an analgesic drug derived from hemp and others, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 7/May/2019, 6.04 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Yes to Autophagy, no to Diabetes: Mechanistic insights into how autophagy may ameliorate Diabetes Mellitus: Acute or intermittent autophagy  augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 5/May/2019, 7.37 am
Yes to Autophagy, no to Diabetes: Mechanistic insights into how autophagy may ameliorate Diabetes Mellitus: Acute or intermittent autophagy  augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 5/May/2019, 7.37 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained…

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