Ideas

Mechanistic insights into how Opioids function as pain medication:  Enkephalin, a pentapeptide that attenuates pain sensation, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 8/April/2019, 10.41 pm
Mechanistic insights into how Opioids function as pain medication:  Enkephalin, a pentapeptide that attenuates pain sensation, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 8/April/2019, 10.41 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University,…

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Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA MALAT1  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 8/April/2019, 10.04 pm
Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA MALAT1  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 8/April/2019, 10.04 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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Repurposing the anti-diabetic drug Metformin into an anti-tuberculosis drug: Metformin (trade name: Glucophage, Glumetza, Glucophage XR, Fortamet), the widely used drug in the treatment of TIIDM,  deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 8/April/2019, 9.50 pm
Repurposing the anti-diabetic drug Metformin into an anti-tuberculosis drug: Metformin (trade name: Glucophage, Glumetza, Glucophage XR, Fortamet), the widely used drug in the treatment of TIIDM,  deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 8/April/2019, 9.50 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore shows…

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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing  Niclosamide and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as p57Kip2, RhoB,  and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 8/April/2018, 9.31 pm
Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing  Niclosamide and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as p57Kip2, RhoB,  and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 8/April/2018, 9.31 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in…

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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancer and other metastatic cancers: A pharmaceutical mixture encompassing Olaparib, an FDA-approved poly (adenosine diphosphate-ribose) polymerase inhibitor, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as IL-1β, HIF4α, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 8/April/2019, 9.15 am
Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancer and other metastatic cancers: A pharmaceutical mixture encompassing Olaparib, an FDA-approved poly (adenosine diphosphate-ribose) polymerase inhibitor, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as IL-1β, HIF4α, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 8/April/2019, 9.15 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Stephenson Cancer Center at the University of Oklahoma, Oklahoma City (K.M.); University of Milan-Bicocca, European Institute of Oncology Istituto di Ricovero e…

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Mechanistic insights into how Calcitonin gene-related peptide (CGRP) causes migraine and headache:  CGRP, a vasoactive peptide known to play a role in the pathophysiology of migraine, decreases the expression of PD-L1, aggravates acute and chronic pain, increases mechanical and thermal hypersensitivity and promotes nociceptive neuron excitability, via down-regulation of its target gene, 6/April/2019, 1.13 pm
Mechanistic insights into how Calcitonin gene-related peptide (CGRP) causes migraine and headache:  CGRP, a vasoactive peptide known to play a role in the pathophysiology of migraine, decreases the expression of PD-L1, aggravates acute and chronic pain, increases mechanical and thermal hypersensitivity and promotes nociceptive neuron excitability, via down-regulation of its target gene, 6/April/2019, 1.13 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University,…

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