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Ideas

September 28, 2018

Turning on the cancer-protecting tumor suppressor network in mutant p53-expressing human tumors: Andrographolide, isolated from Andrographis paniculata, increases the expression of tumor suppressors genes, such as BTG2, CADM1, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/September/2018, 7.14 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 28, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Mibolerone (Trade name: Cheque drops and Matenon), an anabolic-androgenic steroid, increases the expression of tumor suppressors genes, such as FOXO1, APAF1, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/September/2018, 6.29 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 27, 2018

A probiotic way to say no to autoimmune diabetes: Probiotic Lactococcus lactis  increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 27/September/2018, 8.10 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
September 27, 2018

Repurposing the lipid-lowering drug Pitavastatin into a longevity-promoting drug: Statin-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Pitavastatin, Ursolic acid, Maresin, DIM, Ursolic acid  Lutein, Maresin, Cholecalciferol, Catalpol, Isoliquiritigenin (PUMDULMCCI) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via upregulation of its target gene ATG5 (Autophagy-related 5), 27/September/2018, 7.54 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
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