Pain

January 17, 2018

Activation of the PD-1 pathway for Pain therapy: Sildenafil [Phosphodiesterase-5 inhibitor], a drug used in the treatment of erectile dysfunction and pulmonary arterial hypertension,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 17/January/2017, 1.29 pm

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
January 15, 2018

Activation of the PD-1 pathway for Pain therapy: Melatonin[N-acetyl-5-methoxy tryptamine], a hormone that regulates sleep and wakefulness,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 16/January/2017, 4.35 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
December 28, 2017

Activation of the PD-1 pathway for Pain therapy: Diclofenac, a drug used in the treatment of osteoarthritis and migraine,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 29/December/2017, 12.10 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
December 22, 2017

Activation of the PD-1 pathway for Pain therapy: Lycopene (LYC), isolated from Gac, Guava, Tomatoes, and among others,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 23/December/2017, 2.24 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]