This year’s Nobel prize winner for Physiology or Medicine Prof. Sudhof C Thomas (from Stanford University, California, USA) has published a paper in the Journal Cell (2006) stating that “A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.” Subsequently, he has published an article in Journal of Neuroscience (2013) stating that “Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins”
In connection with these findings, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that p53/p63/p73 regulates the complexins/synaptotagmins switch via its target genes. This finding suggests that p63/p73/p53 may regulate Calcium-triggered exocytosis by controlling the expression of Complexins (CPLXs) and Synaptotagmins.
Idea Proposed by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan,Connecting with Nobel’s (Sudhof C Thomas) favorite work: p53/p63/p73 regulates the complexins/synaptotagmins switch via its target genes, 12/October/2013, 8.34 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
* Research cooperation