A study from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.”
This study was published in the June 26, 2014 Nature [I.F >35] by Prof. Puigserver and others from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA.
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Interleukin-based therapy for DM: Inflammatory cytokine Interleukin-27 (IL-27) inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1. This study suggests that IL-27, by down regulating its target gene, it may inhibit gluconeogenesis and hyperglycemia. Together, this study suggests that pharmacological formulations encompassing “IL-27 or its activators“ may be used in the treatment of DM.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., Interleukin-based therapy for DM: Inflammatory cytokine Interleukin-27 (IL-27) inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1., Genome-2-Bio-Medicine Discovery center (GBMD), 12/September/2014, 05.49 am., http://genomediscovery.org
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