A recent study from the Department of Biology, McGill University, H3A 1B1, Montreal, Quebec, Canada shows that “Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.“ This study was published in the 15 October 2005 issue of the journal “Genes & Development” (Impact factor: 12.44) by Prof Hekimi S, Liu X, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Lifespan extension therapy: p73 and p63 promote cellular fitness and life span via up regulation of their target gene
Significance:
This study suggests a Lifespan extension therapy. p73 and p63, by increasing the expression of its target gene, they may decrease the expression of mclk1. Thereby, they may: (1) increase cellular fitness; and (2) extend lifespan. Thus, pharmacological formulations encompassing “p73/p63 activators or small molecule compounds that activate p63/p73 but suppress mclk1“ may be used to increase cellular fitness; and extend lifespan.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Lifespan extension therapy: p73 and p63 promote cellular fitness and life span via up regulation of their target gene, 29/April/2014, 7.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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