Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., MiRNA-based cancer stem cell therapeutics: Tumor suppressor miRNA-140 suppresses the expression of stem cell protein KLF4 and increases the expression of tumor suppressor p53 via down regulation of its target gene, 26/August/2014, 09.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study elucidates, for the first time, that miR-140, by suppressing its target gene, it increases the expression of p53 and decreases the expression of KLF4. Furthermore, this study suggests that pharmacological formulations encompassing ” MiR-140 or its activator” may inhibit cancer stem cell proliferation.