Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, MiRNA-based therapy for Melanoma: Metformin, the widely used drug in the treatment of NIDDM, suppresses the expression of Mcl-1 via up regulation of its target gene , 14/September/2014, 22.07, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that Metformin, by increasing the expression of its target miRNA, it may suppress the expression of Mcl-1. Thereby, it may inhibit invasion and metastatic property of tumor cells. Thus, pharmacological formulations encompassing “Metformin or its related analogs” may used to treat Melanoma.