A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product–based Immune enhancement therapy: Vigna nakashimae extract increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene.
Significance:
Vigna may enhance innate immunity against bacterial infection via up regulation of Sox2
This study suggests, for the first time, that Vigna nakashimae extract, by increasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing “Vigna nakashimae extract or an active compound (s) isolated from it” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product-based Immune enhancement therapy: Vigna nakashimae extract increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 29/September/2016, 8.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Vigna nakashimae extract : (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?