A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published in the online journal “Nature communications” by Prof. Jung YK, Pyo Jo and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based Lifespan extension therapy: Berberine activates autophagy and extends lifespan via up regulation of ATG5
Significance:
This study suggests, for the first time, that Berberine, by increasing the expression of its target gene, it may increase the expression of ATG5. Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features. Thus, pharmacological formulations encompassing “Berberine or its analogs” may be used to increase the life span of an individual.
Idea Proposed/Formulated by: Dr L Boominathan PhD
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To cite: Boominathan, Natural product-based Lifespan extension therapy: Berberine activates autophagy and extends lifespan via up regulation of ATG5, 26/July/2016, 8.44 am
* Research cooperation
