Natural product-based therapy for Metastatic tumors: EF24, the curcumin analogue, suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 20/February/2015, 9.10 am

Natural product-based therapy for Metastatic tumors: EF24, the curcumin analogue, suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 20/February/2015, 9.10 am

Natural product-based therapy for Metastatic tumors: EF24, the curcumin analogue, suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 20/February/2015, 9.10 am 150 150

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product-based therapy for Metastatic tumors: EF24, the curcumin analogue, suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 20/February/2015, 9.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: Curcumin is the major component of turmeric powder. Curcumin has been shown to possess a number of medicinal properties, including anti-cancer property. This study suggests that the curcumin analogue EF24, by suppressing the expression of its target geneit may decrease the expression of PD-1. Thereby, it may activate the immune system that inhibits tumor developmentThus, pharmacological formulations encompassing “EF24 or its analogues  may be used to inhibit the progression of tumors.

Amount: $ 500*

Undisclosed information: How EF-24 suppresses the expression of PD-1

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