A recent study from the Department of Cell Biology-Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School-University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA shows that “Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase” This study was published in the 15 June 2012 issue of the journal “Am J Physiol Heart Circ Physiol” by Prof Ishikawa Y, Iwatsubo K, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy that protects against heart failure: Ursolic acid, enriched in apples, protects against stress-induced heart failure via down regulation of type 5 cardiac adenylyl cyclase.
Significance: It has been shown earlier that ADCY5/AC5 protects against diet-induced weight gain and insulin resistance. This study suggests, for the first time, that Ursolic acid, by decreasing the expression of its target genes, it may suppress the expression of type 5 cardiac adenylyl cyclase (ADCY5/AC5). Thereby, it may inhibit activation of apoptotic pathways, while activating survival pathways in cardiac cells. Thus, pharmacological formulations encompassing “ursolic acid or its analogues“ may be used to treat prevent heart failure.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web: http://genomediscovery.org
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, Natural product-based therapy that protects against heart failure:Ursolic acid, enriched in apples, protects against stress-induced heart failure via down regulation of type 5 cardiac adenylyl cyclase, 29/March/2015, 14.35, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
* Research cooperation