Introduction: What they say:
A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Immune enhancement therapy: (+)-Syringaresinol, isolated from Panax ginseng berry, and Prunus mume, among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene
From Research Findings to Therapeutic Opportunity:
This study suggests, for the first time, (+)-Syringaresinol, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection.
Figure1. (+)-Syringaresinol, isolated from Panax ginseng berry, Prunus mume, as indicated below, promotes innate immunity against bacterial infection via up-regulation of Sox2
Prunus mume
Syringaresinol
Together, pharmacological formulations encompassing “(+)-Syringaresinol or its analogs” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web: http://genomediscovery.org or http://newbioideas.com
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Natural product Immune enhancement therapy: (+)-Syringaresinol, isolated from Panax ginseng berry, and Prunus mume, among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 11/November/2016, 11.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
# Research cooperation
Undisclosed mechanistic information: How (+)-Syringaresinol: (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?
Amount: $300
