What is known:
It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Amifostine/Ethyol, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase the lifespan of an individual.
Figure1. Amifostine/Ethyol may extend mammalian life span via down regulation of mTOR
Together, this study suggests that pharmacological formulations encompassing “Amifostine/Ethyol or its analogues” may function as longevity promoters.
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Web: http://genomediscovery.org or http://newbioideas.com
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Natural product Life-span extension therapy: Amifostine/Ethyol increases life span by suppressing mTOR pathway through up regulation of its target gene, 14/November/2016, 10.02 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
# Research cooperation
Amount: $200
Undisclosed mechanistic information: How does Amifostine/Ethyol decrease the expression of mTOR?
# Research cooperation