A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.
Thymoquinone isolated from Black cumin/ N. Sativa
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3
Significance:
Thymoquinone, by increasing the expression of its target gene, it may decrease the expression of Notch3.
Thymoquinone or its analogue may inhibit pulmonary arterial hypertension via down regulation of Notch-3
Thus, pharmacological formulations encompassing “Thymoquinone or its analogues” may be used to treat pulmonary arterial hypertension.
Undisclosed information: How Thymoquinone decreases the expression of Notch3
Amount:$200#
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Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 1/October/2016, 11.29 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
# Research cooperation