This year’s Nobel prize winner for Physiology or Medicine Prof. Sudhof (Stanford University, California, USA) has published a paper namely “Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.” (J Biol Chem. 2010 Oct 29;285(44):33930-9)
In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that p53/p73/p63 suppresses synaptotagmin-2 transcription in cortical neurons through its target genes. This finding may explain how p53/p63/p73 regulates exocytosis via synaptotagmin-2. Based on this result, Dr Boominathan believes that p53/p63/p73 may play a critical role in the disease pathogenic mechanisms of asthma.
Idea Proposed by: Dr L Boominathan Ph.D.
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To cite: Boominathan, The Follow-up of Nobel laureates’s(Sudhof) favorite work: p53/p73/p63 suppresses synaptotagmin-2 transcription in cortical neurons through its target genes, 9/October/2013, 9.22 am Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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