Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: BMP2 increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 15/June/2014, 8.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that BMP2, by decreasing the expression of its target gene, it may suppress the expression of AT1R. And, thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing “ZOCOR or its analogues” may be used to extend the life-span of an individual.
Undisclosed information: How BMP2 suppresses the expression of angiotensin II type I receptor (AT1R)