A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Natural product Life-extension therapy: Ampelopsin (AMP), a flavonol mainly found in Ampelopsis grossedentata, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Ampelopsin (AMP) , isolated from Ampelopsis grossedentata (commonly known as Mayeam), promotes longevity via downregulation of mTOR and p70 S6 kinase
AMP can be isolated from”Mayeam” . The leaves and stems of Mayeam are used to make a herbal tea generally known as Tujia God/heaven tea. The average life span of those who consume this tea regularly is 89 years.
Significance: This study suggests a natural product-based life extension therapy. Ampelopsin (AMP), by decreasing the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase), it may promote (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity.
Thus, pharmacological formulations encompassing “Ampelopsin (AMP) or its analogues“ can be used to extend the lifespan of an individual.
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Citation: Boominathan, Natural product Life-extension therapy: Ampelopsin (AMP), a flavonol mainly found in Ampelopsis grossedentata, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via upregulation of its target genes, 8/October/2016, 5.24 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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