Significance:
Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin, while its pathway is altered in about 80% of tumors.
This study suggests a therapeutic strategy as to how p53-deficient/deleted or mutant p53 expressing human metastatic cancers can be cured by activating its unmutated or rarely mutated “homologous protein such as TAp63γ” .
Research Findings:
Curcumin, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor TAp63γ. Thereby, it may inhibit the migration and invasion of metastatic cancer cells.
Therapeutic opportunity:
Given that Curcumin may induce the expression of TAp63γ in p53-mutated human tumors, pharmacological formulations encompassing “Curcumin or its analogues” may be used to inhibit the progression of p53-mutated invasive metastatic tumors. Taken together, this study suggests an MiRNA-based therapy for p53-mutated metastatic human tumors.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: Curcumin, one of the main components of turmeric, increases the expression of tumor suppressor p53 homologue TAp63γ and induces regression of p53-mutated human tumors via downregulation of its target gene, 10/October/2016, 6.24 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Curcumin increases the expression of TAp63γ
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