A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in Cancer Science with an impact factor of 19+) by Prof Andrea L. Cox, Park BV and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based PD-1 pathway blockade for Human cancer therapy: Berberine inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene
Significance:
It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year recently.
The study presented here suggests that Berberine, by decreasing the expression of its target gene, it may suppress the expression of PD-1. Thereby, it may (1) increase the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes; (2) augment anti-tumor activity of the immune system; and (3) inhibit metastatic cancer progression.
Berberine, isolated from Oregon grapes, suppresses the expression of PD-1 and augments anti-tumor immunity
Berberine can also be found in Berberis, tree turmeric, goldenseal, yellowroot, Amur cork tree, Chinese goldthread, prickly poppy, and Californian poppy.
Thus, pharmacological formulations encompassing “Berberine or its analogues” may be used to inhibit the progression of tumors.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Natural product-based PD-1 pathway blockade for Human cancer therapy: Berberine inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 10/october/2016, 7.28 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Undisclosed information: How Berberine suppresses the expression of PD-1 and augments anti-tumor immunity
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