What they say:
A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of Notch3 and its target gene Hes-5
Significance of the study:
Curcumin, by increasing the expression of its target gene, it may decrease the expression of Notch3 and its target gene Hes-5 (Fig.1). Thus, pharmacological formulations encompassing “Curcumin or its analogs, either alone or in combination with other drugs” may be used to treat pulmonary arterial hypertension.
Figure 1. Mechanistic insights into how Curcumin (CUR) inhibits the development of pulmonary hypertension via up regulation of its target gene decreases the expression of Notch3
Details of the research findings:
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Undisclosed mechanistic information: How Silymarin inhibits Notch-3 expression
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References:
Web: http://genomediscovery.org or http://newbioideas.com/
Citation: Boominathan, L., Natural product therapy for pulmonary arterial hypertension: Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of Notch3 and its target gene Hes-5, 28/August/2017, 12.14 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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