What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Lifespan extension therapy: Magnolol, found in Houpu magnolia, increases life span via up-regulation of its target gene BubR1
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based life extension therapy. Magnolol, by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing“Magnolol or its analogues, either alone or in combination with drugs” may be used to extend the lifespan of an individual.
Figure 1. Magnolol extends mammalian life span via up regulation of BuBR1.Magnolol extends mammalian life span via up regulation of BuBR1
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Undisclosed information: How Magnolol increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
Reference:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product Lifespan extension therapy: Magnolol, found in Houpu magnolia, increases life span via up-regulation of its target gene BubR1, 24/November/2017, 11.18 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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