What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A flavonoid way to lengthen lifespan: Quercetin, a flavonoid isolated from elder berries, onions and others, may increase insulin sensitivity, slow down cardiac aging, and increase life span, via up-regulation of BubR1 and others genes
From research findings to Therapeutic Opportunity:
This study suggests, for the first time, that Quercetin, by increasing the expression of its target gene, may: (a) increase the expression of BuBR1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase); (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1).
Figure 1. Quercetin may extend mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase
Figure 2. Quercetin functions as longevity-promoter through induction of BuBR1.
Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, Quercetin or its analogues, either alone or in combination with other drugs,“ may be used to extend the lifespan of an individual (fig.2).
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Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Amount: $75
0#
Undisclosed mechanistic information: How Quercetin increase the expression of BubR1 and extend mammalian life-span
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References:
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Citation: Boominathan, L., A flavonoid way to lengthen lifespan: Quercetin, a flavonoid isolated from elder berries, onions and others, may increase insulin sensitivity, slow down cardiac aging, and increase life span, via up-regulation of BubR1 and others genes, 12/July/2018, 12.53 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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