What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Probiotic-based Life-extension therapy: Probiotic lactobacillus reuteri inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span
Research findings to Therapeutic opportunity:
Probiotic lactobacillus reuteri, by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Figure 1. Mechanistic insight into how probiotic lactobacillus reuteri may extend lifespan. Probiotic lactobacillus reuteri inhibits p70 S6 kInase expression and promotes longevity.
Figure 2. Probiotic lactobacillus reuteri functions as a longevity promoter by down regulating the expression of p70S6 kinase.
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Thus, pharmacological formulations encompassing “probiotic lactobacillus reuteri, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 1).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How does Probiotic lactobacillus reuteri decrease the expression of p70 S6 Kinase?
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References:
Citation: Boominathan, L., Probiotic-based Life-extension therapy: Probiotic lactobacillus reuteri inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 25/December/2018, 10.26 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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