Introduction: What they say
A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature Communications”, by Prof. Jung YK, Pyo Jo, and others.
Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of ATG5 in the regulation of autophagy.
What we say:
On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Sesame oil-derived compounds promote lifespan-extension: Sesamin/sesamol-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Sesamin, sesamol, Melatonin, Ursolic acid, Maresin, DIM, Lutein, Ursolic acid Lutein, Maresin, Cholecalciferol Catalpol, Isoliquiritigenin (SSMUMDLCCI) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via upregulation of its target gene ATG5 (Autophagy-related 5)
From research findings to therapeutic opportunity:
While the uses of sesame oil, in treating a number of diseases, is known in India, in ayurvedic medicine, for centuries, Chinese centenarians have used the sesame oil preferably. However, the mechanistic basis of its beneficial effect it either in the treatment of a number of medical conditions or in extension of longevity remains obscure for centuries. This study provides, for the first time, mechanistic insights into how commonly used sesame oil and its constituents, such as Sesamin, and sesamol, may promote lifespan extension.
This study suggests, for the first time, that a therapeutic mix encompassing Sesamin, sesamol, Melatonin, Ursolic acid, Maresin, DIM, Lutein, Ursolic acid Lutein, Maresin, Cholecalciferol Catalpol, Isoliquiritigenin (SSMUMDLCCI), by increasing the expression of its target genes, it may increase the expression of ATG5 (Autophagy-related 5). Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate aging features (Fig.1).
Figure1. A therapeutic mix encompassing Sesamin, sesamol, Melatonin, Ursolic acid, Maresin, DIM, Lutein, Ursolic acid Lutein, Maresin, Cholecalciferol Catalpol, Isoliquiritigenin (SSMUMDLCCI) functions as a longevity promoting agent. The therapeutic mix RCUIMDULMC increases ATG5 expression and promotes leanness, insulin sensitivity, motor function and longevity
Figure 2. Sesame oil-derived compounds, such as Sesamin & sesamol, may promote weight loss, insulin sensitivity, motor function, and extend lifespan, through induction of ATG5 and other longevity-promoting genes
Figure 3. Sesame oil-derived compounds, such as Sesamin & sesamol, extend lifespan through induction of ATG5 and other longevity-promoting genes
Thus, pharmacological formulations encompassing “Sesamin, sesamol, Melatonin, Ursolic acid, Maresin, DIM, Lutein, Ursolic acid Lutein, Maresin, Cholecalciferol Catalpol, Isoliquiritigenin (SSMUMDLCCI) or their analogs, either alone or in combination with drugs,” may be used to increase the lifespan of an individual (Fig.1).
Details of the research findings:
Idea Proposed/Formulated by Dr L Boominathan PhD
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Undisclosed mechanistic information: How does a therapeutic mix encompassing SSMUMDLCCI increase the expression of ATG5 ?
References:
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Citation: Boominathan, L., Sesame oil-derived compounds promote lifespan-extension: Sesamin/sesamol-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Sesamin, sesamol, Melatonin, Ursolic acid, Maresin, DIM, Lutein, Ursolic acid Lutein, Maresin, Cholecalciferol Catalpol, Isoliquiritigenin (SSMUMDLCCI) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via upregulation of its target gene ATG5 (Autophagy-related 5), 6/June/2019, 11.24 pm