Introduction: What they say
A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature Communications”, by Prof. Jung YK, Pyo Jo, and others.
Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of ATG5 in the regulation of autophagy.
What we say:
On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Surgery for Lifespan extension comes of age-Bariatric surgery aids in Lifespan extension: Mechanistic insights into how Bariatric surgery promotes longevity in obese patients and in aged patients: Bariatric surgery activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase
From research findings to therapeutic opportunity:
While the therapeutic benefit of bariatric surgery, in the treatment of obesity and diabetes, is known for decades, the mechanistic basis of its therapeutic effect, in molecular terms, is largely unknown. This study provides, for the first time, mechanistic insights into how bariatric surgery may promote lifespan extension in obese patients and others.
Bariatric surgery, by promoting the expression of its target genes, it may increase the expression of ATG5 (Autophagy-related 5) and Telomerase. Thereby, it: (1) enhances autophagy, (2) promotes leanness; (3) increases insulin sensitivity; (4) improves motor function; (5) increases regeneration of adult stem cells; and (6) alleviates aging features (Fig.1).
Figure1. Mechanistic insights into how bariatric surgery provides life-span extension. Bariatric surgery, by increasing the expression of its target genes, it increases ATG5 (Autophagy-related protein-5), and telomerase expression, augements regeneration of adult stem cells, and promotes leanness, insulin sensitivity, motor function and longevity.
Figure 2. Bariatric surgery, by promoting the expression of ATG5, telomerase, and other longevity-promoting genes, promotes weight loss, insulin sensitivity, and motor function, and extends lifespan
Figure 3. Bariatric surgery extends lifespan through induction of ATG5 (Autophagy-related protein-5), telomerase, and other longevity-promoting genes.
Thus, bariatric surgery can be recommended, not only to extend the lifespan of obese patients, but also the aged people (Fig.1).
Given the mechanistic basis as to how bariatric surgery aids in lifespan-extension, medical practitioners/gastroenterologists/surgical-specialists may consider recommending this to the needy/aged patients or putting this promising finding, with a strong mechanistic basis, which matches with the established anti-ageing mechanisms revealed recently, into a clinical trial.
Details of the research findings:
Idea Proposed/Formulated by Dr L Boominathan PhD
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Undisclosed mechanistic information: How does bariatric surgery increase the expression of ATG5 and telomerase ?
References:
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Citation: Boominathan, L., Surgery for Lifespan extension comes of age-Bariatric surgery aids in Lifespan extension: Mechanistic insights into how Bariatric surgery promotes longevity in obese patients and in aged patients: Bariatric surgery activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 14/July/2019, 10.58 pm